Store this medicine in a safe place, out of reach of children, and away from anyone who could misuse or abuse it. How does Midazolam Nasal affect the brain? Please see package insert.
How does the body digest Midazolam Nasal? Important points about midazolam include: Midazolam is well absorbed after it is given into the nose. It reaches peak amounts in the blood in about 17 minutes. The half-life in adults is between 2 to 6 hours. A half-life refers to how long it takes for the body to get rid of half of the drug.
Midazolam is broken down in the liver and excreted in the urine. How well does the Midazolam Nasal work? People were first given 2 doses of Nayzilam to see how they reacted to the medicine. They were then given either 5 mg of Nayzilam or a placebo to treat a seizure cluster. Seizure clusters stopped in a significantly greater number of people using Nayzilam than those using placebo.
The seizure cluster stopped within 10 minutes in about half of the people using Nayzilam. The seizures did not come back in the next 6 hours.
What are the most common side effects of Midazolam Nasal? Some common side effects include: sleepiness headache runny nose nasal discomfort throat irritation Write down any side effects that happen and tell your health care provider. What are the most serious side effects of Midazolam Nasal?
Read the package insert for more information. Call your provider's office right away if any of these problems occur. These include: Slowed breathing, blocking of the airway, low oxygen levels, change in breathing patterns, heart attack or respiratory breathing arrest. Of note: cardiac or respiratory arrest was not seen during clinical drug trials of midazolam.
Rarely, periods of low blood pressure have been seen when midazolam was given for tests, surgery, or in people with other medical problems. Low blood pressure may happen more often in people who have been given a narcotic pain killer at the same time. The risk of breathing problems is greater in older adults, people with other chronic health problems, and people with other breathing problems. The risk of this is increased if midazolam is used with: Other medications that can depress or affect brain function.
Medicines that inhibit or affect how some medicines work can also cause this risk. One group of these medicines is called CYP3A4 Inhibitors — these drugs can increase side effects of midazolam.
Alcohol or other substances that can affect the brain. Opioids a group of medicines used to treat severe pain can cause severe sedation or sleepiness, slowed breathing, coma, and death if used with midazolam. Before using midazolam, talk to your health care provider about any use of an opioid medicine. Keep close follow-up with your health care team if these medicines are used together. Since this can be life-threatening, if these symptoms occur, get immediate medical help Suicidal thoughts and behavior: Since , the Food and Drug Administration FDA has placed a warning on seizure medications or antiepileptic drugs AEDs used for any reason.
Step 3: Lay your child on their side recovery position. Open their lips and squeeze the remaining midazolam from the ampoule into the inside of the lower cheek closest to the ground , between the lips and side teeth. There is no need to open your child's jaw. The solution does not need to be swallowed. Give three squeezes of the ampoule to make sure it has all been given.
Remove the ampoule to check that all of the solution has been squeezed out. If any remains, reinsert the ampoule and give three more squeezes. Buccal midazolam — syringe method Step 1: Open the plastic ampoule of midazolam by twisting off the top.
Step 2: Insert the syringe into the ampoule and hold the ampoule and syringe upright with the ampoule above the syringe.
Withdraw the required dose as prescribed by your doctor into a 1mL syringe. Push out any big air bubbles and check the amount of midazolam in the syringe. Remove the ampoule from the syringe. Open their lips and slowly trickle the midazolam from the syringe into the inside of the lower cheek closest to the ground , between the lips and side teeth.
Step 4: Watch your child's breathing and seizure activity while they remain lying on their side in the first aid position.
Intranasal midazolam Intranasal midazolam — using a mucosal atomization device e. MAD Step 1: Open the plastic ampoule of midazolam by twisting off the top. Step 2: Insert the syringe into the ampoule and hold the ampoule and syringe upright with the ampoule higher. Pull the ampoule and the syringe apart.
Step 3: Attach the syringe to the mucosal atomization device. Step 4: Lay your child on their side recovery position or in the best position to allow easy administration of intranasal midazolam. Dated January Dated February Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions.
Egton Medical Information Systems Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions. Buccal midazolam is given as an emergency rescue medication during an epileptic seizure fit. In this article About buccal midazolam Before giving buccal midazolam How to use buccal midazolam Getting the most from your treatment Can buccal midazolam cause problems?
How to store buccal midazolam Important information about all medicines. Buccal midazolam for seizures in children Buccolam, Epistatus In this article About buccal midazolam Before giving buccal midazolam How to use buccal midazolam Getting the most from your treatment Can buccal midazolam cause problems?
Common buccal midazolam side-effects What can I do if my child experiences this? Drowsiness, feeling sleepy or falling asleep Stay with your child while they are recovering from the seizure and the effects of this medicine. If you have been shown how, put your child into the recovery position. If your child loses consciousness again after the seizure has stopped, call an ambulance Feeling sick nausea This should soon pass Being sick vomiting If your child is sick vomits after having a dose of buccal midazolam, do not give any further doses and call an ambulance if their seizure does not stop within ten minutes of it starting.
If you have any questions about this medicine ask your pharmacist. The aim of treatment is to stop all of your seizures with the lowest dose of the fewest number of AEDs and with the least side effects. The decision whether to start taking anti-epileptic drugs AEDs can be difficult, and there is a lot to think about. Here we look at the benefits and risks of taking, or not taking, AEDs. Skip to content. Skip to navigation. Site Navigation About epilepsy About epilepsy What is epilepsy?
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Emergency medication.
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